- Title
- The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
- Creator
- Zhu, Youming; Jin, Lei; Zhang, Li Rong; Zhang, Xu Dong; Wu, Mian; Shi, Ronghua; Li, Jinming; Wang, Yan; Zhang, Li; Liang, Chao-Zhao; Narayana, Vinrod K.; De Souza, David P.; Thorne, Rick F.
- Relation
- NHMRC.1147271 http://purl.org/au-research/grants/nhmrc/1147271
- Relation
- Molecular Cell Vol. 82, Issue 3, p. 542-554.e6
- Publisher Link
- http://dx.doi.org/10.1016/j.molcel.2021.11.017
- Publisher
- Cell Press
- Resource Type
- journal article
- Date
- 2022
- Description
- Non-covalent complexes of glycolytic enzymes, called metabolons, were postulated in the 1970s, but the concept has been controversial. Here we show that a c-Myc-responsive long noncoding RNA (lncRNA) that we call glycoLINC (gLINC) acts as a backbone for metabolon formation between all four glycolytic payoff phase enzymes (PGK1, PGAM1, ENO1, and PKM2) along with lactate dehydrogenase A (LDHA). The gLINC metabolon enhances glycolytic flux, increases ATP production, and enables cell survival under serine deprivation. Furthermore, gLINC overexpression in cancer cells promotes xenograft growth in mice fed a diet deprived of serine, suggesting that cancer cells employ gLINC during metabolic reprogramming. We propose that gLINC makes a functional contribution to cancer cell adaptation and provide the first example of a lncRNA-facilitated metabolon.
- Subject
- c-Myc; glycoLINC; glycolytic complex; serine starvation; metabolon; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1473804
- Identifier
- uon:49114
- Identifier
- ISSN:1097-2765
- Language
- eng
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